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recombinant cd3ϵ cd3γ heterodimer protein hfc tag  (Sino Biological)


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    Sino Biological recombinant cd3ϵ cd3γ heterodimer protein hfc tag
    Effect evaluation TCR-like BsAb in HLA/HBV-dTg mice. (A-B) Body weight (A) and serum HBsAg (B) changes in HLA/HBV-dTg mice injected with different doses of TCR-like BsAbs. The three TCR-like BsAbs share the same set of PBS controls (dashed lines). (C) Immunohistochemical staining of MPO, <t>CD3</t> and Cathepsin K in HLA/HBV-dTg mice liver after 75-1452C11 infusion (scale bar = 100 μm). (D) Body weight change (upper panel) and serum HBsAg change (bottom panel) after administration of 75-1452C11, 3G11-1452C11 or 5G1-1452C11 in designated mice, the % is the ratio of the test value to the baseline value. The three TCR-like BsAbs share the same set of PBS controls (dashed lines). The data on the treatment of HLA/HBV-dTg mice with 5G1-1452C11 shown in panel (D) are derived from the data on treatment with 5G1-1452C11at a dosage of 10 mg/kg presented in panels (A) and (B) (dashed lines). All animal experiments were performed with n = 5 and the data are presented as the mean ± SEM. Significant differences in (D) were analyzed by One-way ANOVA followed by Dunnett's multiple comparisons test. Coloured asterisks indicate a comparison of the respective group with the HLA/HBV-dTg group. Asterisks indicate statistical significance: **** P < 0.0001, *** P < 0.001, ** P < 0.01, * P < 0.05, ns no significant.
    Recombinant Cd3ϵ Cd3γ Heterodimer Protein Hfc Tag, supplied by Sino Biological, used in various techniques. Bioz Stars score: 93/100, based on 2 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/recombinant cd3ϵ cd3γ heterodimer protein hfc tag/product/Sino Biological
    Average 93 stars, based on 2 article reviews
    recombinant cd3ϵ cd3γ heterodimer protein hfc tag - by Bioz Stars, 2026-03
    93/100 stars

    Images

    1) Product Images from "TCR-like bispecific antibodies toward eliminating infected hepatocytes in HBV mouse models"

    Article Title: TCR-like bispecific antibodies toward eliminating infected hepatocytes in HBV mouse models

    Journal: Emerging Microbes & Infections

    doi: 10.1080/22221751.2024.2387448

    Effect evaluation TCR-like BsAb in HLA/HBV-dTg mice. (A-B) Body weight (A) and serum HBsAg (B) changes in HLA/HBV-dTg mice injected with different doses of TCR-like BsAbs. The three TCR-like BsAbs share the same set of PBS controls (dashed lines). (C) Immunohistochemical staining of MPO, CD3 and Cathepsin K in HLA/HBV-dTg mice liver after 75-1452C11 infusion (scale bar = 100 μm). (D) Body weight change (upper panel) and serum HBsAg change (bottom panel) after administration of 75-1452C11, 3G11-1452C11 or 5G1-1452C11 in designated mice, the % is the ratio of the test value to the baseline value. The three TCR-like BsAbs share the same set of PBS controls (dashed lines). The data on the treatment of HLA/HBV-dTg mice with 5G1-1452C11 shown in panel (D) are derived from the data on treatment with 5G1-1452C11at a dosage of 10 mg/kg presented in panels (A) and (B) (dashed lines). All animal experiments were performed with n = 5 and the data are presented as the mean ± SEM. Significant differences in (D) were analyzed by One-way ANOVA followed by Dunnett's multiple comparisons test. Coloured asterisks indicate a comparison of the respective group with the HLA/HBV-dTg group. Asterisks indicate statistical significance: **** P < 0.0001, *** P < 0.001, ** P < 0.01, * P < 0.05, ns no significant.
    Figure Legend Snippet: Effect evaluation TCR-like BsAb in HLA/HBV-dTg mice. (A-B) Body weight (A) and serum HBsAg (B) changes in HLA/HBV-dTg mice injected with different doses of TCR-like BsAbs. The three TCR-like BsAbs share the same set of PBS controls (dashed lines). (C) Immunohistochemical staining of MPO, CD3 and Cathepsin K in HLA/HBV-dTg mice liver after 75-1452C11 infusion (scale bar = 100 μm). (D) Body weight change (upper panel) and serum HBsAg change (bottom panel) after administration of 75-1452C11, 3G11-1452C11 or 5G1-1452C11 in designated mice, the % is the ratio of the test value to the baseline value. The three TCR-like BsAbs share the same set of PBS controls (dashed lines). The data on the treatment of HLA/HBV-dTg mice with 5G1-1452C11 shown in panel (D) are derived from the data on treatment with 5G1-1452C11at a dosage of 10 mg/kg presented in panels (A) and (B) (dashed lines). All animal experiments were performed with n = 5 and the data are presented as the mean ± SEM. Significant differences in (D) were analyzed by One-way ANOVA followed by Dunnett's multiple comparisons test. Coloured asterisks indicate a comparison of the respective group with the HLA/HBV-dTg group. Asterisks indicate statistical significance: **** P < 0.0001, *** P < 0.001, ** P < 0.01, * P < 0.05, ns no significant.

    Techniques Used: Injection, Immunohistochemical staining, Staining, Derivative Assay, Comparison



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    Effect evaluation TCR-like BsAb in HLA/HBV-dTg mice. (A-B) Body weight (A) and serum HBsAg (B) changes in HLA/HBV-dTg mice injected with different doses of TCR-like BsAbs. The three TCR-like BsAbs share the same set of PBS controls (dashed lines). (C) Immunohistochemical staining of MPO, <t>CD3</t> and Cathepsin K in HLA/HBV-dTg mice liver after 75-1452C11 infusion (scale bar = 100 μm). (D) Body weight change (upper panel) and serum HBsAg change (bottom panel) after administration of 75-1452C11, 3G11-1452C11 or 5G1-1452C11 in designated mice, the % is the ratio of the test value to the baseline value. The three TCR-like BsAbs share the same set of PBS controls (dashed lines). The data on the treatment of HLA/HBV-dTg mice with 5G1-1452C11 shown in panel (D) are derived from the data on treatment with 5G1-1452C11at a dosage of 10 mg/kg presented in panels (A) and (B) (dashed lines). All animal experiments were performed with n = 5 and the data are presented as the mean ± SEM. Significant differences in (D) were analyzed by One-way ANOVA followed by Dunnett's multiple comparisons test. Coloured asterisks indicate a comparison of the respective group with the HLA/HBV-dTg group. Asterisks indicate statistical significance: **** P < 0.0001, *** P < 0.001, ** P < 0.01, * P < 0.05, ns no significant.
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    Image Search Results


    Effect evaluation TCR-like BsAb in HLA/HBV-dTg mice. (A-B) Body weight (A) and serum HBsAg (B) changes in HLA/HBV-dTg mice injected with different doses of TCR-like BsAbs. The three TCR-like BsAbs share the same set of PBS controls (dashed lines). (C) Immunohistochemical staining of MPO, CD3 and Cathepsin K in HLA/HBV-dTg mice liver after 75-1452C11 infusion (scale bar = 100 μm). (D) Body weight change (upper panel) and serum HBsAg change (bottom panel) after administration of 75-1452C11, 3G11-1452C11 or 5G1-1452C11 in designated mice, the % is the ratio of the test value to the baseline value. The three TCR-like BsAbs share the same set of PBS controls (dashed lines). The data on the treatment of HLA/HBV-dTg mice with 5G1-1452C11 shown in panel (D) are derived from the data on treatment with 5G1-1452C11at a dosage of 10 mg/kg presented in panels (A) and (B) (dashed lines). All animal experiments were performed with n = 5 and the data are presented as the mean ± SEM. Significant differences in (D) were analyzed by One-way ANOVA followed by Dunnett's multiple comparisons test. Coloured asterisks indicate a comparison of the respective group with the HLA/HBV-dTg group. Asterisks indicate statistical significance: **** P < 0.0001, *** P < 0.001, ** P < 0.01, * P < 0.05, ns no significant.

    Journal: Emerging Microbes & Infections

    Article Title: TCR-like bispecific antibodies toward eliminating infected hepatocytes in HBV mouse models

    doi: 10.1080/22221751.2024.2387448

    Figure Lengend Snippet: Effect evaluation TCR-like BsAb in HLA/HBV-dTg mice. (A-B) Body weight (A) and serum HBsAg (B) changes in HLA/HBV-dTg mice injected with different doses of TCR-like BsAbs. The three TCR-like BsAbs share the same set of PBS controls (dashed lines). (C) Immunohistochemical staining of MPO, CD3 and Cathepsin K in HLA/HBV-dTg mice liver after 75-1452C11 infusion (scale bar = 100 μm). (D) Body weight change (upper panel) and serum HBsAg change (bottom panel) after administration of 75-1452C11, 3G11-1452C11 or 5G1-1452C11 in designated mice, the % is the ratio of the test value to the baseline value. The three TCR-like BsAbs share the same set of PBS controls (dashed lines). The data on the treatment of HLA/HBV-dTg mice with 5G1-1452C11 shown in panel (D) are derived from the data on treatment with 5G1-1452C11at a dosage of 10 mg/kg presented in panels (A) and (B) (dashed lines). All animal experiments were performed with n = 5 and the data are presented as the mean ± SEM. Significant differences in (D) were analyzed by One-way ANOVA followed by Dunnett's multiple comparisons test. Coloured asterisks indicate a comparison of the respective group with the HLA/HBV-dTg group. Asterisks indicate statistical significance: **** P < 0.0001, *** P < 0.001, ** P < 0.01, * P < 0.05, ns no significant.

    Article Snippet: In multiple ELISA assays, recombinant CD3ϵ & CD3γ heterodimer protein hFc Tag (Sino Biological inc, CT061-M02H) was coated, and then BsAbs, recombinant pHLA complexes, and HRP conjugated anti-β2 m antibody are subsequently added.

    Techniques: Injection, Immunohistochemical staining, Staining, Derivative Assay, Comparison